PHARMACOKINETIC SUBSTANTIATION OF THE THERAPEUTIC EFFICACY OF ANTISEPTIC PREPARATION CYDIPOL IN TREATMENT OF PROSTATITIS

• Main Authors: Kravchenko V. G., Ivanov L. V., Derimedved L. V., Shcherbak O. V.
• Format: Article
• Language: English
• Published: Ukrainian Medical Stomatological Academy 2018-12-01
• Series: Вісник проблем біології і медицини
• Subjects: pharmacokinetics; prostatitis; Cidipol; rectal administration; suppositories
• Online Access: https://vpbm.com.ua/upload/2018-4-2/33-min.pdf

Improving the treatment of prostatitis is an urgent task, since many means and methods of treating this ailment do not always achieve the desired result, which is largely due to the topographic-anatomical features of the prostate gland and pathological changes in its gistostructures in the course of the disease. For Cidipol, taking into account its pharmacokinetic properties, it is possible to overcome tissue barriers, an experimental study of its therapeutic efficacy in prostatitis was quite reasonable. Ìain goal of the research is to substantiate theoretically and experimentally the usage of Cydipol, a preparation with a broad spectrum of pharmacological activity for the treatment of prostatitis when applied rectally. Research methods were pharmacokinetic, gas and liquid chromatography, with rectal application of Cidipol to laboratory animals (rabbits), with further extrapolating of the results of previously obtained data on the study of preparations containing , as well as Cidipol, nitroxyl group (Ciminal and Nitazol) at rectal application Results and consideration. The pharmacokinetics of Cidipol is characterized by slow absorption of ciminial with a semi-absorption period for 1.1 hours, Tmax = 2.5 hours and rather slow removal of ciminal from animals body (T0.5 = 5.1 hours, Kel = 0.13). The effectiveness of the local method of administration of Cidipol directly depends on its lipophilicity and well-marked membrane-forming properties, which enable the preparation to quickly diffuse through the numerous cell membranes of the tissues. A significant amount of PEG 400 in the drug Cidipol provides maximum bioavailability of cimenal in the tissue of the prostate, rectum and colon. Findings. The specific pharmacokinetic profile and pharmacokinetic parameters of Cidipol for rectal application suggest that Cidipol has all the properties as a remedy in the form of suppositories, ointments or thick fluids for the treatment both prostatitis and colorectal diseases. Medicinal forms with Cidipol (suppositories, ointments, gels) can provide direct diffusion of pharmaceutical substance into the tissues of the prostate and the rectum mucus through the tissues of rectum mucous membrane, and not the systemic flow, based on the close proximity of the gland to the place of application of the drug. One can positively consider the prospects of the same dosage forms of Cidipol for the treatment of various cervicitis and vaginitis, including microbial-fungal. Cidipol should be considered as a holistic pharmaceutical system, in which there are no excipients, but there are only active ingredients that provide a significant contribution to the formation of the overall therapeutic efficacy of the complex.