Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function

Seasonal decomposition analyses were applied to the statistical evaluation of an oscillating activity for a plasma membrane NADH oxidase activity with a temperature compensated period of 24 min. The decomposition fits were used to validate the cyclic oscillatory pattern. Three measured values, avera...

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Main Authors: Ken Foster, Nasim Anwar, Rhea Pogue, Dorothy M. Morré, T. W. Keenan, D. James Morré
Format: Article
Language:English
Published: SAGE Publishing 2003-01-01
Series:Dose-Response
Online Access:https://doi.org/10.1080/15401420390844465
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spelling doaj-900f724e0ce549aaba55bd5f4384b16a2020-11-25T03:46:03ZengSAGE PublishingDose-Response1559-32582003-01-01110.1080/15401420390844465Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) FunctionKen FosterNasim Anwar0Rhea Pogue1Dorothy M. Morré2T. W. Keenan3D. James Morré4 Department of Medicinal Chemistry and Molecular Pharmacology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0308 Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA Department of Biochemistry and Anaerobic Microbiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0308 Department of Medicinal Chemistry and Molecular Pharmacology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0308Seasonal decomposition analyses were applied to the statistical evaluation of an oscillating activity for a plasma membrane NADH oxidase activity with a temperature compensated period of 24 min. The decomposition fits were used to validate the cyclic oscillatory pattern. Three measured values, average percentage error (MAPE), a measure of the periodic oscillation, mean average deviation (MAD), a measure of the absolute average deviations from the fitted values, and mean standard deviation (MSD), the measure of standard deviation from the fitted values plus R-squared and the Henriksson-Merton p value were used to evaluate accuracy. Decomposition was carried out by fitting a trend line to the data, then detrending the data if necessary, by subtracting the trend component. The data, with or without detrending, were then smoothed by subtracting a centered moving average of length equal to the period length determined by Fourier analysis. Finally, the time series were decomposed into cyclic and error components. The findings not only validate the periodic nature of the major oscillations but suggest, as well, that the minor intervening fluctuations also recur within each period with a reproducible pattern of recurrence.https://doi.org/10.1080/15401420390844465
collection DOAJ
language English
format Article
sources DOAJ
author Ken Foster
Nasim Anwar
Rhea Pogue
Dorothy M. Morré
T. W. Keenan
D. James Morré
spellingShingle Ken Foster
Nasim Anwar
Rhea Pogue
Dorothy M. Morré
T. W. Keenan
D. James Morré
Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function
Dose-Response
author_facet Ken Foster
Nasim Anwar
Rhea Pogue
Dorothy M. Morré
T. W. Keenan
D. James Morré
author_sort Ken Foster
title Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function
title_short Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function
title_full Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function
title_fullStr Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function
title_full_unstemmed Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function
title_sort decomposition analyses applied to a complex ultradian biorhythm: the oscillating nadh oxidase activity of plasma membranes having a potential time-keeping (clock) function
publisher SAGE Publishing
series Dose-Response
issn 1559-3258
publishDate 2003-01-01
description Seasonal decomposition analyses were applied to the statistical evaluation of an oscillating activity for a plasma membrane NADH oxidase activity with a temperature compensated period of 24 min. The decomposition fits were used to validate the cyclic oscillatory pattern. Three measured values, average percentage error (MAPE), a measure of the periodic oscillation, mean average deviation (MAD), a measure of the absolute average deviations from the fitted values, and mean standard deviation (MSD), the measure of standard deviation from the fitted values plus R-squared and the Henriksson-Merton p value were used to evaluate accuracy. Decomposition was carried out by fitting a trend line to the data, then detrending the data if necessary, by subtracting the trend component. The data, with or without detrending, were then smoothed by subtracting a centered moving average of length equal to the period length determined by Fourier analysis. Finally, the time series were decomposed into cyclic and error components. The findings not only validate the periodic nature of the major oscillations but suggest, as well, that the minor intervening fluctuations also recur within each period with a reproducible pattern of recurrence.
url https://doi.org/10.1080/15401420390844465
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