Association between severity of depression and clinico-biochemical markers of polycystic ovary syndrome

• Main Authors: Behnaz Enjezab, Maryam Eftekhar, Akram Ghadiri-Anari
• Format: Article
• Language: English
• Published: Electronic Physician 2017-11-01
• Series: Electronic Physician
• Subjects: Polycystic ovary syndrome; Depression; Insulin resistance; Testosterone
• Online Access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783134/
• ISSN: 2008-5842; 2008-5842

Background: Polycystic ovary syndrome (PCOS), as the most common endocrine disorder among reproductive- aged women may lead to psychological morbidity. Objectives: The present study set out to evaluate the severity of depression in PCOS and non-PCOS women and to evaluate correlation between depression score with body mass index, HOMA-IR, and testosterone level in every group (PCOS and non-PCOS women) in Yazd province. Methods: In this cross-sectional study, 62 women with PCOS and 61 non- PCOS subjects (20 to 40 years) who were attending Imam-Ali Clinic in Yazd, Iran from September 2014 through March 2015 participated. These persons completed the Beck Depression Short Inventory (BDI-S) Questionnaire. Frequency of depression in PCOD and healthy persons and correlation between depression severity with body mass index, HOMA-IR, testosterone level in PCOS and non- PCOS women were evaluated by ANOVA test and independent-samples ttest and Pearson correlation. P-value of less than 0.05 was considered as statistically significant. Data analyses were performed using SPSS version 16. Results: Of 62 PCOS subjects, 40 (64.5%) were verified positive for depression, determined by the BDI-S Questionnaire. In the control group, 60.7% had depression. Mean±SE score of depression for PCOS and non- PCOS women were 7.47±5.54 and 7.57±5.77 respectively. There was no statistically significant correlation between body mass index, HOMA-IR, testosterone level with depression score in either group separately or together. Conclusions: We found considerable amounts of depression in our population. There is no correlation between body mass index, HOMA-IR, and testosterone level with depression score in our study.