5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma

5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma

Tumors evolve a variety of mechanisms to escape immune detection while expressing tumor-promoting molecules that can be immunogenic. Here, we show that transposable elements (TE) and gene encoded, tumor-associated antigens (TAA), which can be both highly immunogenic and tumor-promoting, are signific...

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Bibliographic Details
Main Authors: Nancy D. Ebelt, Edith Zuniga, Benjamin L. Johnson, Don J. Diamond, Edwin R. Manuel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
pancreatic ductal adenocarcinoma
transposable element
5-azacytidine
anti-tumor immunity
tumor-associated antigens
immune evasion
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00538/full

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