Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A 11C-donepezil PET Study

Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A 11C-donepezil PET Study

Objective(s): It is difficult to investigate the whole-body distribution of an orally administered drug by means of positron emission tomography (PET), owing to the short physical half-life of radionuclides, especially when 11C-labeled compounds are tested. Therefore, we aimed to examine the whole-b...

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Bibliographic Details
Main Authors: Ikuko Mochida, Eku Shimosegawa, Yasukazu Kanai, Sadahiro Naka, Jun Hatazawa, Keiko Matsunaga, Kayako Isohashi, Genki Horitsugi, Tadashi Watabe, Hiroki Kato
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2017-01-01
Series:Asia Oceania Journal of Nuclear Medicine and Biology
Subjects:
11C-DNP PET
oral dosing
Donepezil
Online Access:http://aojnmb.mums.ac.ir/article_7513_9bd7a0c496ac120a8d3c2f04137c3fce.pdf

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http://aojnmb.mums.ac.ir/article_7513_9bd7a0c496ac120a8d3c2f04137c3fce.pdf

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