Cytomegalovirus-Specific CD8+ T-Cells With Different T-Cell Receptor Affinities Segregate T-Cell Phenotypes and Correlate With Chronic Graft-Versus-Host Disease in Patients Post-Hematopoietic Stem Cell Transplantation

Cytomegalovirus-Specific CD8+ T-Cells With Different T-Cell Receptor Affinities Segregate T-Cell Phenotypes and Correlate With Chronic Graft-Versus-Host Disease in Patients Post-Hematopoietic Stem Cell Transplantation

Virus-specific T-cell responses are crucial to control cytomegalovirus (CMV) infections/reactivation in immunocompromised individuals. Adoptive cellular therapy with CMV-specific T-cells has become a viable treatment option. High-affinity anti-viral cellular immune responses are associated with impr...

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Bibliographic Details
Main Authors: Thomas Poiret, Rebecca Axelsson-Robertson, Mats Remberger, Xiao-Hua Luo, Martin Rao, Anurupa Nagchowdhury, Anna Von Landenberg, Ingemar Ernberg, Olle Ringden, Markus Maeurer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
cytomegalovirus
cytomegalovirus-specific CD8+ cytotoxic T-lymphocytes
T-cell receptor affinity
T-cell
hematopoietic stem cell transplantation
programmed cell death-1
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00760/full

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