Protective Effect of Memantine on Bergmann Glia and Purkinje Cells Morphology in Optogenetic Model of Neurodegeneration in Mice

Protective Effect of Memantine on Bergmann Glia and Purkinje Cells Morphology in Optogenetic Model of Neurodegeneration in Mice

Spinocerebellar ataxias are a family of fatal inherited diseases affecting the brain. Although specific mutated proteins are different, they may have a common pathogenetic mechanism, such as insufficient glutamate clearance. This function fails in reactive glia, leading to excitotoxicity and overact...

Full description

Bibliographic Details
Main Authors: Anton N. Shuvaev, Olga S. Belozor, Oleg I. Mozhei, Elena D. Khilazheva, Andrey N. Shuvaev, Yana V. Fritsler, S. Kasparov
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
astrogliosis
optogenetics
Bergmann glia
ataxia
cerebellar neurodegeneration
glutamate uptake
Online Access:https://www.mdpi.com/1422-0067/22/15/7822

Internet

https://www.mdpi.com/1422-0067/22/15/7822

Similar Items