Extracellular Domain N-Glycosylation Controls Human Thrombopoietin Receptor Cell Surface Levels

Extracellular Domain N-Glycosylation Controls Human Thrombopoietin Receptor Cell Surface Levels

The thrombopoietin receptor (TpoR) is a type I transmembrane protein that mediates the signaling functions of thrombopoietin (Tpo) in regulating megakaryocyte differentiation, platelet formation and hematopoietic stem cell renewal. We probed the role of each of the four extracellular domain putative...

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Bibliographic Details
Main Authors: Roxana I. Albu, Stefan N. eConstantinescu
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Endocrinology
Subjects:
Signal Transduction
Thrombopoietin
cytokine receptor
JAK2
cell surface traffic
Endoglycosidase H
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00071/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00071/full

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