Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge....

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Bibliographic Details
Main Authors: Csanova A., Jezova D.
Format: Article
Language:English
Published: Sciendo 2016-09-01
Series:European Pharmaceutical Journal
Subjects:
immune challenge
kynurenine-3-monooxygenase
gender
Online Access:https://doi.org/10.1515/afpuc-2016-0009
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spelling doaj-8fae5765827d4a489bfa39368e302a622021-09-06T19:39:44ZengSciendoEuropean Pharmaceutical Journal2453-67252016-09-01631202210.1515/afpuc-2016-0009afpuc-2016-0009Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in ratsCsanova A.0Jezova D.1Slovak Academy of Sciences, Biomedical Research Center, Institution of Experimental Endocrinology, Bratislava,SlovakiaSlovak Academy of Sciences, Biomedical Research Center, Institution of Experimental Endocrinology, Bratislava,SlovakiaThe neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites.https://doi.org/10.1515/afpuc-2016-0009immune challengekynurenine-3-monooxygenasegender
collection DOAJ
language English
format Article
sources DOAJ
author Csanova A.
Jezova D.
spellingShingle Csanova A.
Jezova D.
Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats
European Pharmaceutical Journal
immune challenge
kynurenine-3-monooxygenase
gender
author_facet Csanova A.
Jezova D.
author_sort Csanova A.
title Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats
title_short Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats
title_full Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats
title_fullStr Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats
title_full_unstemmed Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats
title_sort stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats
publisher Sciendo
series European Pharmaceutical Journal
issn 2453-6725
publishDate 2016-09-01
description The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites.
topic immune challenge
kynurenine-3-monooxygenase
gender
url https://doi.org/10.1515/afpuc-2016-0009
work_keys_str_mv AT csanovaa stimulatoryeffectofrepeatedtreatmentwithlipopolysaccharideonakeyenzymeofthekynureninepathwayinbothgendersinrats
AT jezovad stimulatoryeffectofrepeatedtreatmentwithlipopolysaccharideonakeyenzymeofthekynureninepathwayinbothgendersinrats
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