Effects of indoleamine 2,3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation.

Effects of indoleamine 2,3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation.

Hepatic immune regulation is associated with the progression from simple steatosis to non-alcoholic steatohepatitis, a severe condition of inflamed fatty liver. Indoleamine 2,3-dioxygenase (IDO), an intracellular enzyme that mediates the catabolism of L-tryptophan to L-kynurenine, plays an important...

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Bibliographic Details
Main Authors: Junji Nagano, Masahito Shimizu, Takeshi Hara, Yohei Shirakami, Takahiro Kochi, Nobuhiko Nakamura, Hirofumi Ohtaki, Hiroyasu Ito, Takuji Tanaka, Hisashi Tsurumi, Kuniaki Saito, Mitsuru Seishima, Hisataka Moriwaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3767792?pdf=render

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