The increasing doses of methotrexate pharmacokinetics after intravenous administration in rats - model selection

The increasing doses of methotrexate pharmacokinetics after intravenous administration in rats - model selection

Background/Aim. Methotrexate (MTX) plays a significant role in the treatment of various diseases, but the toxicity remains the main issue of its use, especially when administered in high doses. Considering altered pharmacokinetics of MTX as a factor strongly implicated in the large interpatient vari...

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Main Authors: Rajšić Ivana, Pavlović Nebojša, Milijašević Boris, Vukmirović Saša, Spasić Dragan, Žigić Miodrag, Grahovac Nenad, Goločorbin-Kon Svetlana, Mikov Momir
Format: Article
Language:English
Published: Military Health Department, Ministry of Defance, Serbia 2021-01-01
Series:Vojnosanitetski Pregled
Subjects:
methotrexate
pharmacokinetics
high dose
biodistribution
two-compartment model
fractional calculus
Online Access:http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900126R.pdf

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