The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumul...

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Bibliographic Details
Main Authors: Julien Bricambert, Marie-Clotilde Alves-Guerra, Pauline Esteves, Carina Prip-Buus, Justine Bertrand-Michel, Hervé Guillou, Christopher J. Chang, Mark N. Vander Wal, François Canonne-Hergaux, Philippe Mathurin, Violeta Raverdy, François Pattou, Jean Girard, Catherine Postic, Renaud Dentin
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04361-y

Internet

https://doi.org/10.1038/s41467-018-04361-y

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