All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration

Abstract Liver is the largest internal organ that serves as the key site for various metabolic activities and maintenance of homeostasis. Liver diseases are great threats to human health. The capability of liver to regain its mass after partial hepatectomy has widely been applied in treating liver d...

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Main Authors: Ce Gao, Jinrong Peng
Format: Article
Language:English
Published: SpringerOpen 2021-01-01
Series:Cell Regeneration
Online Access:https://doi.org/10.1186/s13619-020-00063-3
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spelling doaj-8f99107d0bf1426391f05d2abe0980622021-01-10T12:37:05ZengSpringerOpenCell Regeneration2045-97692021-01-0110111010.1186/s13619-020-00063-3All routes lead to Rome: multifaceted origin of hepatocytes during liver regenerationCe Gao0Jinrong Peng1MOE Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, Zhejiang UniversityMOE Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, Zhejiang UniversityAbstract Liver is the largest internal organ that serves as the key site for various metabolic activities and maintenance of homeostasis. Liver diseases are great threats to human health. The capability of liver to regain its mass after partial hepatectomy has widely been applied in treating liver diseases either by removing the damaged part of a diseased liver in a patient or transplanting a part of healthy liver into a patient. Vast efforts have been made to study the biology of liver regeneration in different liver-damage models. Regarding the sources of hepatocytes during liver regeneration, convincing evidences have demonstrated that different liver-damage models mobilized different subtype hepatocytes in contributing to liver regeneration. Under extreme hepatocyte ablation, biliary epithelial cells can undergo dedifferentiation to liver progenitor cells (LPCs) and then LPCs differentiate to produce hepatocytes. Here we will focus on summarizing the progresses made in identifying cell types contributing to producing new hepatocytes during liver regeneration in mice and zebrafish.https://doi.org/10.1186/s13619-020-00063-3
collection DOAJ
language English
format Article
sources DOAJ
author Ce Gao
Jinrong Peng
spellingShingle Ce Gao
Jinrong Peng
All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration
Cell Regeneration
author_facet Ce Gao
Jinrong Peng
author_sort Ce Gao
title All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration
title_short All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration
title_full All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration
title_fullStr All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration
title_full_unstemmed All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration
title_sort all routes lead to rome: multifaceted origin of hepatocytes during liver regeneration
publisher SpringerOpen
series Cell Regeneration
issn 2045-9769
publishDate 2021-01-01
description Abstract Liver is the largest internal organ that serves as the key site for various metabolic activities and maintenance of homeostasis. Liver diseases are great threats to human health. The capability of liver to regain its mass after partial hepatectomy has widely been applied in treating liver diseases either by removing the damaged part of a diseased liver in a patient or transplanting a part of healthy liver into a patient. Vast efforts have been made to study the biology of liver regeneration in different liver-damage models. Regarding the sources of hepatocytes during liver regeneration, convincing evidences have demonstrated that different liver-damage models mobilized different subtype hepatocytes in contributing to liver regeneration. Under extreme hepatocyte ablation, biliary epithelial cells can undergo dedifferentiation to liver progenitor cells (LPCs) and then LPCs differentiate to produce hepatocytes. Here we will focus on summarizing the progresses made in identifying cell types contributing to producing new hepatocytes during liver regeneration in mice and zebrafish.
url https://doi.org/10.1186/s13619-020-00063-3
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AT jinrongpeng allroutesleadtoromemultifacetedoriginofhepatocytesduringliverregeneration
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