Elevated Expression of Serum Amyloid A 3 Protects Colon Epithelium Against Acute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis

Elevated Expression of Serum Amyloid A 3 Protects Colon Epithelium Against Acute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis

Induced expression of serum amyloid A (SAA) is a hallmark of many inflammatory diseases, but whether SAA exacerbates inflammation or protects tissues against injury remains unclear. In dextran sulfate sodium (DSS)-induced colitis, SAA3 is the predominant isoform of inducible SAA proteins that also i...

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Bibliographic Details
Main Authors: Gufang Zhang, Jin Liu, Lehao Wu, Yu Fan, Lei Sun, Feng Qian, Daijie Chen, Richard D. Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
serum amyloid A
inflammation
innate immunity
cytokines
colitis
neutrophils
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01503/full

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