Coumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies

Coumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies

Fourteen coumarin-derived compounds modified at the C3 carbon of coumarin with an α,β-unsaturated ketone were synthesized. These compounds may be designated as chalcocoumarins (3-cinnamoyl-2<i>H</i>-chromen-2-ones). Both chalcones and coumarins are recognized scaffolds in medicinal chemi...

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Main Authors: Guillermo Moya-Alvarado, Osvaldo Yañez, Nicole Morales, Angélica González-González, Carlos Areche, Marco Tulio Núñez, Angélica Fierro, Olimpo García-Beltrán
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
chalcocoumarin
MAO-B
molecular dynamics
in silico studies
neurodegenerative diseases
Online Access:https://www.mdpi.com/1420-3049/26/9/2430

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