Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways

Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways

Liver fibrosis is an abnormal proliferation of connective tissue in the liver caused by various pathogenic factors. Chronic liver injury leads to release of inflammatory cytokines and reactive oxygen species (ROS) from damaged hepatocytes, which activates hepatic stellate cells (HSCs) to secrete ext...

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Bibliographic Details
Main Authors: Zhiyong Li, Zhilei Wang, Fang Dong, Wei Shi, Wenzhang Dai, Jing Zhao, Qiang Li, Zhi-e Fang, Lutong Ren, Tingting Liu, Ziying Wei, Wenqing Mou, Li Lin, Yan Yang, Xiaohe Xiao, Li Ma, Zhaofang Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
ROS: reactive oxygen species
HSCs: hepatic stellate cells
germacrone
TGF-β/Smad pathway
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.745561/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.745561/full

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