Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

Following ischemic insult, neovascularization and vascular remodelling play an essential part in the repair of brain damage. Here the authors show that neutrophil extracellular traps serve a detrimental role in the regeneration process, limiting the functional recovery of the brain post injury.

Bibliographic Details
Main Authors: Lijing Kang, Huilin Yu, Xing Yang, Yuanbo Zhu, Xiaofei Bai, Ranran Wang, Yongliang Cao, Haochen Xu, Haiyu Luo, Lu Lu, Mei-Juan Shi, Yujing Tian, Wenying Fan, Bing-Qiao Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16191-y
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spelling doaj-8f7fbaa734844099aa177ffef624709f2021-05-23T11:15:34ZengNature Publishing GroupNature Communications2041-17232020-05-0111111510.1038/s41467-020-16191-yNeutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after strokeLijing Kang0Huilin Yu1Xing Yang2Yuanbo Zhu3Xiaofei Bai4Ranran Wang5Yongliang Cao6Haochen Xu7Haiyu Luo8Lu Lu9Mei-Juan Shi10Yujing Tian11Wenying Fan12Bing-Qiao Zhao13Department of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityDepartment of Translational Neuroscience, Jing’an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan UniversityFollowing ischemic insult, neovascularization and vascular remodelling play an essential part in the repair of brain damage. Here the authors show that neutrophil extracellular traps serve a detrimental role in the regeneration process, limiting the functional recovery of the brain post injury.https://doi.org/10.1038/s41467-020-16191-y
collection DOAJ
language English
format Article
sources DOAJ
author Lijing Kang
Huilin Yu
Xing Yang
Yuanbo Zhu
Xiaofei Bai
Ranran Wang
Yongliang Cao
Haochen Xu
Haiyu Luo
Lu Lu
Mei-Juan Shi
Yujing Tian
Wenying Fan
Bing-Qiao Zhao
spellingShingle Lijing Kang
Huilin Yu
Xing Yang
Yuanbo Zhu
Xiaofei Bai
Ranran Wang
Yongliang Cao
Haochen Xu
Haiyu Luo
Lu Lu
Mei-Juan Shi
Yujing Tian
Wenying Fan
Bing-Qiao Zhao
Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
Nature Communications
author_facet Lijing Kang
Huilin Yu
Xing Yang
Yuanbo Zhu
Xiaofei Bai
Ranran Wang
Yongliang Cao
Haochen Xu
Haiyu Luo
Lu Lu
Mei-Juan Shi
Yujing Tian
Wenying Fan
Bing-Qiao Zhao
author_sort Lijing Kang
title Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
title_short Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
title_full Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
title_fullStr Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
title_full_unstemmed Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
title_sort neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-05-01
description Following ischemic insult, neovascularization and vascular remodelling play an essential part in the repair of brain damage. Here the authors show that neutrophil extracellular traps serve a detrimental role in the regeneration process, limiting the functional recovery of the brain post injury.
url https://doi.org/10.1038/s41467-020-16191-y
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