The DEAH-box helicase Dhr1 dissociates U3 from the pre-rRNA to promote formation of the central pseudoknot.

The DEAH-box helicase Dhr1 dissociates U3 from the pre-rRNA to promote formation of the central pseudoknot.

In eukaryotes, the highly conserved U3 small nucleolar RNA (snoRNA) base-pairs to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events. Binding of the U3 box A region to the pre-rRNA is mutually exclusive with folding of the central pseudoknot (CPK), a univ...

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Bibliographic Details
Main Authors: Richa Sardana, Xin Liu, Sander Granneman, Jieyi Zhu, Michael Gill, Ophelia Papoulas, Edward M Marcotte, David Tollervey, Carl C Correll, Arlen W Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002083

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