Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

Triple Negative Breast Cancer (TNBC) is aggressive, metastatic and drug-resistant, limiting the spectrum of effective therapeutic options for breast cancer patients. To date, anti-angiogenic agents have had limited success in the treatment of systemic breast cancer, possibly due to the exacerbation...

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Bibliographic Details
Main Authors: Eva-Maria E. Hedlund, Paul C. McDonald, Oksana Nemirovsky, Shannon Awrey, Lasse D.E. Jensen, Shoukat Dedhar
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
angiogenesis
carbonic anhydrase IX
hypoxia
metastasis
resistance
sunitinib
triple negative breast cancer
Online Access:https://www.mdpi.com/2072-6694/11/7/1002

Internet

https://www.mdpi.com/2072-6694/11/7/1002

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