nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors

nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors

Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.

Bibliographic Details
Main Authors: Hai-Ying Liang, Zhi-Jin Chen, Hui Xiao, Yu-Hui Lin, Ying-Yi Hu, Lei Chang, Hai-Yin Wu, Peng Wang, Wei Lu, Dong-Ya Zhu, Chun-Xia Luo
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16198-5
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spelling doaj-8f56e6d3aab84052a130814cd81530482021-05-23T11:14:10ZengNature Publishing GroupNature Communications2041-17232020-05-0111111810.1038/s41467-020-16198-5nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviorsHai-Ying Liang0Zhi-Jin Chen1Hui Xiao2Yu-Hui Lin3Ying-Yi Hu4Lei Chang5Hai-Yin Wu6Peng Wang7Wei Lu8Dong-Ya Zhu9Chun-Xia Luo10Department of Pharmacology, School of Pharmacy, Nanjing Medical UniversityDepartment of Pharmacology, School of Pharmacy, Nanjing Medical UniversityDepartment of Pharmacology, School of Pharmacy, Nanjing Medical UniversityDepartment of Pharmacology, School of Pharmacy, Nanjing Medical UniversityDepartment of Pharmacology, School of Pharmacy, Nanjing Medical UniversityDepartment of Pharmacology, School of Pharmacy, Nanjing Medical UniversityDepartment of Pharmacology, School of Pharmacy, Nanjing Medical UniversityState Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Pharmaceutical Co. Ltd.State Key Laboratory of Bioelectronics, The MOE Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast UniversityDepartment of Pharmacology, School of Pharmacy, Nanjing Medical UniversityDepartment of Pharmacology, School of Pharmacy, Nanjing Medical UniversityChronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.https://doi.org/10.1038/s41467-020-16198-5
collection DOAJ
language English
format Article
sources DOAJ
author Hai-Ying Liang
Zhi-Jin Chen
Hui Xiao
Yu-Hui Lin
Ying-Yi Hu
Lei Chang
Hai-Yin Wu
Peng Wang
Wei Lu
Dong-Ya Zhu
Chun-Xia Luo
spellingShingle Hai-Ying Liang
Zhi-Jin Chen
Hui Xiao
Yu-Hui Lin
Ying-Yi Hu
Lei Chang
Hai-Yin Wu
Peng Wang
Wei Lu
Dong-Ya Zhu
Chun-Xia Luo
nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
Nature Communications
author_facet Hai-Ying Liang
Zhi-Jin Chen
Hui Xiao
Yu-Hui Lin
Ying-Yi Hu
Lei Chang
Hai-Yin Wu
Peng Wang
Wei Lu
Dong-Ya Zhu
Chun-Xia Luo
author_sort Hai-Ying Liang
title nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_short nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_full nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_fullStr nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_full_unstemmed nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
title_sort nnos-expressing neurons in the vmpfc transform ppvt-derived chronic pain signals into anxiety behaviors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-05-01
description Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.
url https://doi.org/10.1038/s41467-020-16198-5
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