nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.
Bibliographic Details
| Main Authors: |
Hai-Ying Liang,
Zhi-Jin Chen,
Hui Xiao,
Yu-Hui Lin,
Ying-Yi Hu,
Lei Chang,
Hai-Yin Wu,
Peng Wang,
Wei Lu,
Dong-Ya Zhu,
Chun-Xia Luo |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-16198-5
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