Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry

Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry

Thermo-responsive cross-linkable <i>m</i>PEG-<i>b</i>-[PCL-<i>g</i>-(MEO<sub>2</sub>MA-<i>co</i>-OEGMA)]-<i>b</i>-<i>m</i>PEG was synthesized by ring-opening polymerization (ROP) and atom transfer radical polymerizat...

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Main Authors: Pei Shang, Jie Wu, Xiaoyu Shi, Zhidan Wang, Fei Song, Shouxin Liu
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Polymers
Subjects:
<i>ε</i>-Caprolactone
block-graft copolymer
click chemistry hydrogel
Online Access:https://www.mdpi.com/2073-4360/11/5/765
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spelling doaj-8f3c74ae266b4e318cdeb205d694c7c52020-11-25T02:07:04ZengMDPI AGPolymers2073-43602019-05-0111576510.3390/polym11050765polym11050765Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click ChemistryPei Shang0Jie Wu1Xiaoyu Shi2Zhidan Wang3Fei Song4Shouxin Liu5Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, ChinaKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, ChinaKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, ChinaKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, ChinaKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, ChinaKey Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, ChinaThermo-responsive cross-linkable <i>m</i>PEG-<i>b</i>-[PCL-<i>g</i>-(MEO<sub>2</sub>MA-<i>co</i>-OEGMA)]-<i>b</i>-<i>m</i>PEG was synthesized by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Then, the cross-linkable block-graft copolymer was used to prepare hydrogel via a copper-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction. The chemical structure and composition of copolymer were characterized by proton nuclear magnetic resonance (<sup>1</sup>H NMR), Fourier-transform infrared (FT-IR) and gel permeation chromatography (GPC). The self-assembly behaviors of the copolymer in aqueous solution were studied by UV spectrophotometer, fluorescence probes, the surface tension method, dynamic light scattering, and transmission electron microscopy. The results proved that the copolymer has excellent solubility and better temperature response. The three-dimensional network structure of the gels, observed by scanning electron microscopy at different temperatures, indicated that the gels have temperature response.https://www.mdpi.com/2073-4360/11/5/765<i>ε</i>-Caprolactoneblock-graft copolymerclick chemistry hydrogel
collection DOAJ
language English
format Article
sources DOAJ
author Pei Shang
Jie Wu
Xiaoyu Shi
Zhidan Wang
Fei Song
Shouxin Liu
spellingShingle Pei Shang
Jie Wu
Xiaoyu Shi
Zhidan Wang
Fei Song
Shouxin Liu
Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry
Polymers
<i>ε</i>-Caprolactone
block-graft copolymer
click chemistry hydrogel
author_facet Pei Shang
Jie Wu
Xiaoyu Shi
Zhidan Wang
Fei Song
Shouxin Liu
author_sort Pei Shang
title Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry
title_short Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry
title_full Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry
title_fullStr Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry
title_full_unstemmed Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry
title_sort synthesis of thermo-responsive block-graft copolymer based on pcl and peg analogs, and preparation of hydrogel via click chemistry
publisher MDPI AG
series Polymers
issn 2073-4360
publishDate 2019-05-01
description Thermo-responsive cross-linkable <i>m</i>PEG-<i>b</i>-[PCL-<i>g</i>-(MEO<sub>2</sub>MA-<i>co</i>-OEGMA)]-<i>b</i>-<i>m</i>PEG was synthesized by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Then, the cross-linkable block-graft copolymer was used to prepare hydrogel via a copper-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction. The chemical structure and composition of copolymer were characterized by proton nuclear magnetic resonance (<sup>1</sup>H NMR), Fourier-transform infrared (FT-IR) and gel permeation chromatography (GPC). The self-assembly behaviors of the copolymer in aqueous solution were studied by UV spectrophotometer, fluorescence probes, the surface tension method, dynamic light scattering, and transmission electron microscopy. The results proved that the copolymer has excellent solubility and better temperature response. The three-dimensional network structure of the gels, observed by scanning electron microscopy at different temperatures, indicated that the gels have temperature response.
topic <i>ε</i>-Caprolactone
block-graft copolymer
click chemistry hydrogel
url https://www.mdpi.com/2073-4360/11/5/765
work_keys_str_mv AT peishang synthesisofthermoresponsiveblockgraftcopolymerbasedonpclandpeganalogsandpreparationofhydrogelviaclickchemistry
AT jiewu synthesisofthermoresponsiveblockgraftcopolymerbasedonpclandpeganalogsandpreparationofhydrogelviaclickchemistry
AT xiaoyushi synthesisofthermoresponsiveblockgraftcopolymerbasedonpclandpeganalogsandpreparationofhydrogelviaclickchemistry
AT zhidanwang synthesisofthermoresponsiveblockgraftcopolymerbasedonpclandpeganalogsandpreparationofhydrogelviaclickchemistry
AT feisong synthesisofthermoresponsiveblockgraftcopolymerbasedonpclandpeganalogsandpreparationofhydrogelviaclickchemistry
AT shouxinliu synthesisofthermoresponsiveblockgraftcopolymerbasedonpclandpeganalogsandpreparationofhydrogelviaclickchemistry
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