Dose-dependent dual role of PIT-1 (POU1F1) in somatolactotroph cell proliferation and apoptosis.

Dose-dependent dual role of PIT-1 (POU1F1) in somatolactotroph cell proliferation and apoptosis.

To test the role of wtPIT-1 (PITWT) or PIT-1 (R271W) (PIT271) in somatolactotroph cells, we established, using inducible lentiviral vectors, sublines of GH4C1 somatotroph cells that allow the blockade of the expression of endogenous PIT-1 and/or the expression of PITWT or PIT271, a dominant negative...

Full description

Bibliographic Details
Main Authors: Nicolas Jullien, Catherine Roche, Thierry Brue, Dominique Figarella-Branger, Thomas Graillon, Anne Barlier, Jean-Paul Herman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4379079?pdf=render

Internet

http://europepmc.org/articles/PMC4379079?pdf=render

Similar Items