Effects of Selective Substitution of Cysteine Residues on the Conformational Properties of Chlorotoxin Explored by Molecular Dynamics Simulations

Effects of Selective Substitution of Cysteine Residues on the Conformational Properties of Chlorotoxin Explored by Molecular Dynamics Simulations

Chlorotoxin (CTX) is a 36–amino acid peptide with eight Cys residues that forms four disulfide bonds. It has high affinity for the glioma-specific chloride channel and matrix metalloprotease-2. Structural and binding properties of CTX analogs with various Cys residue substitutions with l-&...

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Bibliographic Details
Main Authors: Andrew J. Gregory, Leah Voit-Ostricki, Sándor Lovas, Charles R. Watts
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
αβ motif
Abu
chlorotoxin
Cys
disulfide bond
insectotoxin
isosteric substitution
l-α-aminobutyric acid
molecular dynamics
Ser
Online Access:http://www.mdpi.com/1422-0067/20/6/1261

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http://www.mdpi.com/1422-0067/20/6/1261

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