Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

Dysregulation of microtubules and tubulin homeostasis has been linked to developmental disorders, neurodegenerative diseases, and cancer. In general, both microtubule-stabilizing and destabilizing agents have been powerful tools for studies of microtubule cytoskeleton and as clinical agents in oncol...

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Bibliographic Details
Main Authors: Ivana Gasic, Brian J. Groendyke, Radosław P. Nowak, J. Christine Yuan, Joann Kalabathula, Eric S. Fischer, Nathanael S. Gray, Timothy J. Mitchison
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
microtubule
tubulin
PROTAC
Online Access:https://www.mdpi.com/2073-4409/9/5/1083

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