Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

CesT is a type III secretion system chaperone that interacts with the post-transcriptional regulator CsrA, which is important for the modulation of post-attachment signaling in enteropathogenic and enterohemorrhagic Escherichia coli. Here the authors present the structure of the CsrA/CesT complex an...

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Main Authors:	Fei Ye, Fanli Yang, Ruijie Yu, Xi Lin, Jianxun Qi, Zhujun Chen, Yu Cao, Yuquan Wei, George F. Gao, Guangwen Lu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03625-x

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spelling	doaj-8f293fd685dc4dd88d5f15dce483bb3a2021-05-11T09:54:12ZengNature Publishing GroupNature Communications2041-17232018-03-019111110.1038/s41467-018-03625-xMolecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesTFei Ye0Fanli Yang1Ruijie Yu2Xi Lin3Jianxun Qi4Zhujun Chen5Yu Cao6Yuquan Wei7George F. Gao8Guangwen Lu9West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of BiotherapyWest China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of BiotherapyWest China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of BiotherapyWest China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of BiotherapyCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesWest China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of BiotherapyWest China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of BiotherapyWest China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of BiotherapyCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesWest China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of BiotherapyCesT is a type III secretion system chaperone that interacts with the post-transcriptional regulator CsrA, which is important for the modulation of post-attachment signaling in enteropathogenic and enterohemorrhagic Escherichia coli. Here the authors present the structure of the CsrA/CesT complex and propose a mechanism for CsrA-modulation by CesT.https://doi.org/10.1038/s41467-018-03625-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fei Ye Fanli Yang Ruijie Yu Xi Lin Jianxun Qi Zhujun Chen Yu Cao Yuquan Wei George F. Gao Guangwen Lu
spellingShingle	Fei Ye Fanli Yang Ruijie Yu Xi Lin Jianxun Qi Zhujun Chen Yu Cao Yuquan Wei George F. Gao Guangwen Lu Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT Nature Communications
author_facet	Fei Ye Fanli Yang Ruijie Yu Xi Lin Jianxun Qi Zhujun Chen Yu Cao Yuquan Wei George F. Gao Guangwen Lu
author_sort	Fei Ye
title	Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT
title_short	Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT
title_full	Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT
title_fullStr	Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT
title_full_unstemmed	Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT
title_sort	molecular basis of binding between the global post-transcriptional regulator csra and the t3ss chaperone cest
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	CesT is a type III secretion system chaperone that interacts with the post-transcriptional regulator CsrA, which is important for the modulation of post-attachment signaling in enteropathogenic and enterohemorrhagic Escherichia coli. Here the authors present the structure of the CsrA/CesT complex and propose a mechanism for CsrA-modulation by CesT.
url	https://doi.org/10.1038/s41467-018-03625-x
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Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

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