Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression
Varicoceles (VCs) are the predominant cause of male infertility and are a risk factor for chronic venous disease. Morinda officinalis (M. officinalis) is a traditional Chinese medicine used to tonify the kidney and strengthen yang. In this study, we evaluated the effects of water-soluble polysacchar...
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2017/9057959 |
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doaj-8f286305674142c59dcb9f36b621da232020-11-24T20:56:50ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882017-01-01201710.1155/2017/90579599057959Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele ProgressionZhu Zhu0Feng Huang1Feng Wang2Yonghong Zhang3Xiaozhen Zhao4Wei Wang5Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, ChinaDepartment of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, ChinaDepartment of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, ChinaSchool of Pharmacy, Fujian Medical University, Fuzhou 350122, ChinaDepartment of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, ChinaDepartment of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, ChinaVaricoceles (VCs) are the predominant cause of male infertility and are a risk factor for chronic venous disease. Morinda officinalis (M. officinalis) is a traditional Chinese medicine used to tonify the kidney and strengthen yang. In this study, we evaluated the effects of water-soluble polysaccharides extracted from M. officinalis (MOPs) on gonadotropin-release hormone (GnRH) secretion in a classic experimental left VC (ELV) rat model. Intragastric administration of MOPs at a dose ranging from 50 mg kg−1 to 100 mg kg−1 facilitated improvements in sperm parameters and seminiferous epithelial structures, modulated serum hormone profiles, and stimulated GnRH synthesis and release in the hypothalamus. MOPs also promoted spinogenesis and functional spine maturation in the arcuate nuclei (Arc), wherein they acted mainly on Kiss1 and GnRH neurons. Moreover, MOP-mediated Kisspeptin-GPR54 pathway upregulation and MAPK phosphorylation activation may have been responsible for increases in GnRH synthesis and release. Collectively, the findings of this study indicate that MOPs were effective in stimulating GnRH secretion, possibly by upregulating the Kiss1/GPR54 pathway and enhancing synaptic plasticity, and that MOPs can serve as a therapy for early VCs.http://dx.doi.org/10.1155/2017/9057959 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhu Zhu Feng Huang Feng Wang Yonghong Zhang Xiaozhen Zhao Wei Wang |
spellingShingle |
Zhu Zhu Feng Huang Feng Wang Yonghong Zhang Xiaozhen Zhao Wei Wang Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression Evidence-Based Complementary and Alternative Medicine |
author_facet |
Zhu Zhu Feng Huang Feng Wang Yonghong Zhang Xiaozhen Zhao Wei Wang |
author_sort |
Zhu Zhu |
title |
Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression |
title_short |
Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression |
title_full |
Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression |
title_fullStr |
Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression |
title_full_unstemmed |
Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression |
title_sort |
morinda officinalis polysaccharides stimulate hypothalamic gnrh secretion in varicocele progression |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2017-01-01 |
description |
Varicoceles (VCs) are the predominant cause of male infertility and are a risk factor for chronic venous disease. Morinda officinalis (M. officinalis) is a traditional Chinese medicine used to tonify the kidney and strengthen yang. In this study, we evaluated the effects of water-soluble polysaccharides extracted from M. officinalis (MOPs) on gonadotropin-release hormone (GnRH) secretion in a classic experimental left VC (ELV) rat model. Intragastric administration of MOPs at a dose ranging from 50 mg kg−1 to 100 mg kg−1 facilitated improvements in sperm parameters and seminiferous epithelial structures, modulated serum hormone profiles, and stimulated GnRH synthesis and release in the hypothalamus. MOPs also promoted spinogenesis and functional spine maturation in the arcuate nuclei (Arc), wherein they acted mainly on Kiss1 and GnRH neurons. Moreover, MOP-mediated Kisspeptin-GPR54 pathway upregulation and MAPK phosphorylation activation may have been responsible for increases in GnRH synthesis and release. Collectively, the findings of this study indicate that MOPs were effective in stimulating GnRH secretion, possibly by upregulating the Kiss1/GPR54 pathway and enhancing synaptic plasticity, and that MOPs can serve as a therapy for early VCs. |
url |
http://dx.doi.org/10.1155/2017/9057959 |
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