Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital

Infections due to extended spectrum β-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae have become an important clinical problem. Local knowledge of antimicrobial susceptibilities of these organisms is important for implementation of effective hospital anti-infective polic...

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Main Author: B. Sasirekha, R. Manasa, P. Ramya and R. Sneha
Format: Article
Language:English
Published: Al Ameen Medical College 2010-10-01
Series:Al Ameen Journal of Medical Sciences
Subjects:
Online Access:http://ajms.alameenmedical.org/article_Vol03-4-oct-dec-2010/AJMS.3.4.2010.265.pdf
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spelling doaj-8f266a72100f4bee8d50fa7ecaddffd22020-11-24T21:41:24ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11432010-10-010304265271Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care HospitalB. Sasirekha, R. Manasa, P. Ramya and R. SnehaInfections due to extended spectrum β-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae have become an important clinical problem. Local knowledge of antimicrobial susceptibilities of these organisms is important for implementation of effective hospital anti-infective policies. The present study was undertaken to determine the prevalence of ESBLs along with their antimicrobial sensitivity pattern in Escherichia coli and klebsiella pneumoniae isolates at a tertiary care hospital in Bangalore. A total of 243 clinical isolates comprising E. coli (n=157) and K. pneumoniae (n=86) were recovered from various clinical samples over a period of six months from June to November 2008. Antibiogram profile of these isolates was determined by Kirby-Bauer’s disc diffusion method. All the isolates were screened for ESBL production as recommended by the Clinical Laboratory Standard Institute (CLSI). The present findings revealed a high occurrence of multidrug resistance ESBL producing E. coli (61.1%) and K. pneumoniae (40.6%). Imipenem was highly active against ESBL producing isolates. Results indicate that routine ESBL detection should be made imperative and empirical use of third generation cephaolsporins must be discouraged.http://ajms.alameenmedical.org/article_Vol03-4-oct-dec-2010/AJMS.3.4.2010.265.pdfExtended spectrum β-lactamasesEscherichia coliKlebsiella pneumoniaethird generation cephalosporin
collection DOAJ
language English
format Article
sources DOAJ
author B. Sasirekha, R. Manasa, P. Ramya and R. Sneha
spellingShingle B. Sasirekha, R. Manasa, P. Ramya and R. Sneha
Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital
Al Ameen Journal of Medical Sciences
Extended spectrum β-lactamases
Escherichia coli
Klebsiella pneumoniae
third generation cephalosporin
author_facet B. Sasirekha, R. Manasa, P. Ramya and R. Sneha
author_sort B. Sasirekha, R. Manasa, P. Ramya and R. Sneha
title Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital
title_short Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital
title_full Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital
title_fullStr Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital
title_full_unstemmed Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital
title_sort frequency and antimicrobial sensitivity pattern of extended spectrum β-lactamases producing e. coli and klebsiella pneumoniae isolated in a tertiary care hospital
publisher Al Ameen Medical College
series Al Ameen Journal of Medical Sciences
issn 0974-1143
publishDate 2010-10-01
description Infections due to extended spectrum β-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae have become an important clinical problem. Local knowledge of antimicrobial susceptibilities of these organisms is important for implementation of effective hospital anti-infective policies. The present study was undertaken to determine the prevalence of ESBLs along with their antimicrobial sensitivity pattern in Escherichia coli and klebsiella pneumoniae isolates at a tertiary care hospital in Bangalore. A total of 243 clinical isolates comprising E. coli (n=157) and K. pneumoniae (n=86) were recovered from various clinical samples over a period of six months from June to November 2008. Antibiogram profile of these isolates was determined by Kirby-Bauer’s disc diffusion method. All the isolates were screened for ESBL production as recommended by the Clinical Laboratory Standard Institute (CLSI). The present findings revealed a high occurrence of multidrug resistance ESBL producing E. coli (61.1%) and K. pneumoniae (40.6%). Imipenem was highly active against ESBL producing isolates. Results indicate that routine ESBL detection should be made imperative and empirical use of third generation cephaolsporins must be discouraged.
topic Extended spectrum β-lactamases
Escherichia coli
Klebsiella pneumoniae
third generation cephalosporin
url http://ajms.alameenmedical.org/article_Vol03-4-oct-dec-2010/AJMS.3.4.2010.265.pdf
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