Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital
Infections due to extended spectrum β-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae have become an important clinical problem. Local knowledge of antimicrobial susceptibilities of these organisms is important for implementation of effective hospital anti-infective polic...
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Al Ameen Medical College
2010-10-01
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doaj-8f266a72100f4bee8d50fa7ecaddffd22020-11-24T21:41:24ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11432010-10-010304265271Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care HospitalB. Sasirekha, R. Manasa, P. Ramya and R. SnehaInfections due to extended spectrum β-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae have become an important clinical problem. Local knowledge of antimicrobial susceptibilities of these organisms is important for implementation of effective hospital anti-infective policies. The present study was undertaken to determine the prevalence of ESBLs along with their antimicrobial sensitivity pattern in Escherichia coli and klebsiella pneumoniae isolates at a tertiary care hospital in Bangalore. A total of 243 clinical isolates comprising E. coli (n=157) and K. pneumoniae (n=86) were recovered from various clinical samples over a period of six months from June to November 2008. Antibiogram profile of these isolates was determined by Kirby-Bauer’s disc diffusion method. All the isolates were screened for ESBL production as recommended by the Clinical Laboratory Standard Institute (CLSI). The present findings revealed a high occurrence of multidrug resistance ESBL producing E. coli (61.1%) and K. pneumoniae (40.6%). Imipenem was highly active against ESBL producing isolates. Results indicate that routine ESBL detection should be made imperative and empirical use of third generation cephaolsporins must be discouraged.http://ajms.alameenmedical.org/article_Vol03-4-oct-dec-2010/AJMS.3.4.2010.265.pdfExtended spectrum β-lactamasesEscherichia coliKlebsiella pneumoniaethird generation cephalosporin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
B. Sasirekha, R. Manasa, P. Ramya and R. Sneha |
spellingShingle |
B. Sasirekha, R. Manasa, P. Ramya and R. Sneha Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital Al Ameen Journal of Medical Sciences Extended spectrum β-lactamases Escherichia coli Klebsiella pneumoniae third generation cephalosporin |
author_facet |
B. Sasirekha, R. Manasa, P. Ramya and R. Sneha |
author_sort |
B. Sasirekha, R. Manasa, P. Ramya and R. Sneha |
title |
Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital |
title_short |
Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital |
title_full |
Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital |
title_fullStr |
Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital |
title_full_unstemmed |
Frequency and Antimicrobial Sensitivity Pattern Of Extended Spectrum β-Lactamases Producing E. Coli And Klebsiella Pneumoniae Isolated In A Tertiary Care Hospital |
title_sort |
frequency and antimicrobial sensitivity pattern of extended spectrum β-lactamases producing e. coli and klebsiella pneumoniae isolated in a tertiary care hospital |
publisher |
Al Ameen Medical College |
series |
Al Ameen Journal of Medical Sciences |
issn |
0974-1143 |
publishDate |
2010-10-01 |
description |
Infections due to extended spectrum β-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae have become an important clinical problem. Local knowledge of antimicrobial susceptibilities of these organisms is important for implementation of effective hospital anti-infective policies. The present study was undertaken to determine the prevalence of ESBLs along with their antimicrobial sensitivity pattern in Escherichia coli and klebsiella pneumoniae isolates at a tertiary care hospital in Bangalore. A total of 243 clinical isolates comprising E. coli (n=157) and K. pneumoniae (n=86) were recovered from various clinical samples over a period of six months from June to November 2008. Antibiogram profile of these isolates was determined by Kirby-Bauer’s disc diffusion method. All the isolates were screened for ESBL production as recommended by the Clinical Laboratory Standard Institute (CLSI). The present findings revealed a high occurrence of multidrug resistance ESBL producing E. coli (61.1%) and K. pneumoniae (40.6%). Imipenem was highly active against ESBL producing isolates. Results indicate that routine ESBL detection should be made imperative and empirical use of third generation cephaolsporins must be discouraged. |
topic |
Extended spectrum β-lactamases Escherichia coli Klebsiella pneumoniae third generation cephalosporin |
url |
http://ajms.alameenmedical.org/article_Vol03-4-oct-dec-2010/AJMS.3.4.2010.265.pdf |
work_keys_str_mv |
AT bsasirekharmanasapramyaandrsneha frequencyandantimicrobialsensitivitypatternofextendedspectrumblactamasesproducingecoliandklebsiellapneumoniaeisolatedinatertiarycarehospital |
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