MLL1 is required for PAX7 expression and satellite cell self-renewal in mice

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice

PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7...

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Main Authors: Gregory C. Addicks, Caroline E. Brun, Marie-Claude Sincennes, John Saber, Christopher J. Porter, A. Francis Stewart, Patricia Ernst, Michael A. Rudnicki
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12086-9
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spelling doaj-8f1a223e30424b10ab115c2947e3f1852021-05-11T11:39:42ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-12086-9MLL1 is required for PAX7 expression and satellite cell self-renewal in miceGregory C. Addicks0Caroline E. Brun1Marie-Claude Sincennes2John Saber3Christopher J. Porter4A. Francis Stewart5Patricia Ernst6Michael A. Rudnicki7Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstituteSprott Centre for Stem Cell Research, Ottawa Bioinformatics Core Facility, Ottawa Hospital Research InstituteGenomics, Center for Molecular and Cellular Bioengineering, Technische Universität DresdenDepartment of Pediatrics and Pharmacology, University of Colorado/Anschutz Medical CampusSprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research InstitutePAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7 and Myf5 expression, and proliferation defects.https://doi.org/10.1038/s41467-019-12086-9
collection DOAJ
language English
format Article
sources DOAJ
author Gregory C. Addicks
Caroline E. Brun
Marie-Claude Sincennes
John Saber
Christopher J. Porter
A. Francis Stewart
Patricia Ernst
Michael A. Rudnicki
spellingShingle Gregory C. Addicks
Caroline E. Brun
Marie-Claude Sincennes
John Saber
Christopher J. Porter
A. Francis Stewart
Patricia Ernst
Michael A. Rudnicki
MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
Nature Communications
author_facet Gregory C. Addicks
Caroline E. Brun
Marie-Claude Sincennes
John Saber
Christopher J. Porter
A. Francis Stewart
Patricia Ernst
Michael A. Rudnicki
author_sort Gregory C. Addicks
title MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_short MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_full MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_fullStr MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_full_unstemmed MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
title_sort mll1 is required for pax7 expression and satellite cell self-renewal in mice
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4me3 at both Pax7 and Myf5 promoters, reduced Pax7 and Myf5 expression, and proliferation defects.
url https://doi.org/10.1038/s41467-019-12086-9
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