Opc expression, LPS immunotype switch and pilin conversion contribute to serum resistance of unencapsulated meningococci.

Opc expression, LPS immunotype switch and pilin conversion contribute to serum resistance of unencapsulated meningococci.

Neisseria meningitidis employs polysaccharides and outer membrane proteins to cope with human serum complement attack. To screen for factors influencing serum resistance, an assay was developed based on a colorimetric serum bactericidal assay. The screening used a genetically modified sequence type...

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Bibliographic Details
Main Authors: Kerstin Hubert, Marie-Christin Pawlik, Heike Claus, Hanna Jarva, Seppo Meri, Ulrich Vogel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3447861?pdf=render

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