Intracranial Fungal Granulomas Mimicking High Grade Gliomas. A Decisive Role of Squash Cytology (SC): A Report of Two Cases

• Main Authors: Parth A. Desai, Ronak K. Patel, Nita Khurana, P.N. Pandey
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2015-01-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: fungal mass lesions; granuloma; intraoperative cytology; neurosurgery; squash cytology
• Online Access: https://jcdr.net/articles/PDF/5440/11321_CE(RA1)_F(T)_PF1(NJAK)_PFA(AK)_PFA2(AK)_PF2(PAG).pdf

Intracranial fungal granulomas can be misdiagnosed clinically and radiologically as neoplastic lesions. They also rarely occur without any history of immunodeficiency or diabetes. We report two such cases of fungal granulomas that were unsuspected clinically and radiologically but were detected on intraoperative squash cytology (SC) and later confirmed on histopathology. Timely intervention was hence possible and patient was saved from the hazards of unnecessary removal of eloquent areas of brain and was shifted on proper medical management. SC remains an indispensible tool for the neurosurgeon to get a provisional intraoperative diagnosis and in such surprising scenarios, change the surgical management of the patient, save the resection of eloquent brain areas and begin immediate postoperative medical management. These cases are being presented for their rarity and for highlighting the importance of SC as a regular tool for intraoperative neurosurgical consultation of intracranial mass lesions.