Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration

Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration

Abstract Background Human muscle-derived stem cells (hMDSCs) have been shown to regenerate bone efficiently when they were transduced with Lenti-viral bone morphogenetic protein 2 (LBMP2). However, whether the age of hMDSCs and the animal host affect the bone regeneration capacity of hMDSCs and mech...

Full description

Bibliographic Details
Main Authors: Xueqin Gao, Aiping Lu, Ying Tang, Johannes Schneppendahl, Andrea B. Liebowitz, Alex C. Scibetta, Elizabeth R. Morris, Haizi Cheng, Charles Huard, Sarah Amra, Bing Wang, Mary A. Hall, Walter R. Lowe, Johnny Huard
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Stem Cell Research & Therapy
Subjects:
Bone morphogenetic protein 2 (BMP2)
Human muscle-derived stem cells (hMDSCs)
Calvarial bone defect
Bone regeneration
Gene therapy
Aging
Online Access:http://link.springer.com/article/10.1186/s13287-018-1066-z

Internet

http://link.springer.com/article/10.1186/s13287-018-1066-z

Similar Items