Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration in ALS

Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration in ALS

Selective motor neuron degeneration is a hallmark of amyotrophic lateral sclerosis (ALS). Around 10 percent of all cases present as familial ALS (FALS), while sporadic ALS (SALS) accounts for the remaining 90 percent. Diverse genetic mutations leading to FALS have been identified, but the underlyin...

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Bibliographic Details
Main Authors: Brittany M Edens, Nimrod eMiller, Yong-Chao eMa
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Autophagy
Mitochondria
Motor Neuron Disease
Oxidative Stress
ALS
calcium homeostasis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00044/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00044/full

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