PU.1 and Haematopoietic Cell Fate: Dosage Matters

The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will disc...

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Bibliographic Details
Main Authors: Ka Sin Mak, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Cell Biology
Online Access:http://dx.doi.org/10.1155/2011/808524