Synaptic loss and amyloid beta alterations in the rodent hippocampus induced by streptozotocin injection into the cisterna magna

Synaptic loss and amyloid beta alterations in the rodent hippocampus induced by streptozotocin injection into the cisterna magna

Abstract To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the pathology of human sporadic AD involves intracerebroventricular (ICV) injection wit...

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Main Authors: Yujin Ahn, Jincheol Seo, Junghyung Park, Jinyoung Won, Hyeon-Gu Yeo, Keonwoo Kim, Chang-Yeop Jeon, Jae-Won Huh, Sang-Rae Lee, Dong-Seok Lee, Youngjeon Lee
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Laboratory Animal Research
Subjects:
Alzheimer’s disease
Streptozotocin
Cisterna magna
Online Access:http://link.springer.com/article/10.1186/s42826-020-00049-x

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