Increased HERV-E clone 4–1 expression contributes to DNA hypomethylation and IL-17 release from CD4+ T cells via miR-302d/MBD2 in systemic lupus erythematosus

Increased HERV-E clone 4–1 expression contributes to DNA hypomethylation and IL-17 release from CD4+ T cells via miR-302d/MBD2 in systemic lupus erythematosus

Abstract Background Increased human endogenous retroviruses E clone 4–1 (HERV-E clone 4–1) mRNA expression is observed in systemic lupus erythematosus (SLE) patients and associates with the disease activity. In this study, we want to further investigate the mechanism of HERV-E clone 4–1 mRNA upregul...

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Bibliographic Details
Main Authors: Xin Wang, Chaoshuai Zhao, Chengzhong Zhang, Xingyu Mei, Jun Song, Yue Sun, Zhouwei Wu, Weimin Shi
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cell Communication and Signaling
Subjects:
HERV-E clone 4–1
Systemic lupus erythematosus
Transcription factors
DNA hypomethylation
miR-302d
MBD2
Online Access:http://link.springer.com/article/10.1186/s12964-019-0416-5

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