CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain

CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain

Adeno-associated viral (AAV) vectors are attractive tools for central nervous system (CNS) gene therapy because some vectors can cross the blood-brain barrier (BBB), allowing them to be used as minimally invasive treatments. A novel AAV vector recently evolved in vivo, AAV-PHP.eB, has been reported...

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Bibliographic Details
Main Authors: Sophie N. Mathiesen, Jasmine L. Lock, Lucia Schoderboeck, Wickliffe C. Abraham, Stephanie M. Hughes
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
viral vector
AAV
AAV9
AAV-PHP.eB
gene therapy
central nervous system
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120302151

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