E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development.
Poly-ubiquitination of target proteins typically marks them for destruction via the proteasome and provides an essential mechanism for the dynamic control of protein levels. The E1 ubiquitin-activating enzyme lies at the apex of the ubiquitination cascade, and its activity is necessary for all subse...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2443343?pdf=render |