Stepwise evolution and convergent recombination underlie the global dissemination of carbapenemase-producing Escherichia coli

Stepwise evolution and convergent recombination underlie the global dissemination of carbapenemase-producing Escherichia coli

Abstract Background Carbapenem-resistant Enterobacteriaceae are considered by WHO as “critical” priority pathogens for which novel antibiotics are urgently needed. The dissemination of carbapenemase-producing Escherichia coli (CP-Ec) in the community is a major public health concern. However, the gl...

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Bibliographic Details
Main Authors: Rafael Patiño-Navarrete, Isabelle Rosinski-Chupin, Nicolas Cabanel, Lauraine Gauthier, Julie Takissian, Jean-Yves Madec, Monzer Hamze, Remy A. Bonnin, Thierry Naas, Philippe Glaser
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Genome Medicine
Subjects:
Carbapenems
Bacterial evolution
Lateral gene transfers
Multidrug resistance
Porin
Penicillin-binding proteins
Online Access:https://doi.org/10.1186/s13073-019-0699-6

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