Photoacoustic effect invokes auditory response in infrared neuron stimulation

• Main Authors: Muqun Yang, Tian Guan, Yonghong He
• Format: Article
• Language: English
• Published: World Scientific Publishing 2019-01-01
• Series: Journal of Innovative Optical Health Sciences
• Subjects: Infrared neuron stimulation; optical compound action potential; photoacoustic effect
• Online Access: http://www.worldscientific.com/doi/pdf/10.1142/S1793545818500402

Infrared neuron stimulation is regarded as an innovative approach for stimulating cochleae in animals while the exact mechanism still remains unknown. In this paper, we studied compound action potentials of guinea pig cochleae with chronic or acute deafness. We recorded optical compound action potentials and analyzed stretched cochlear preparations by fluorescence microscopy. Photoacoustic signals were measured by hydrophone and microphone, respectively. In our experiment, we observed a switch response effect in vitro and in vivo experiments. Therefore, we proposed photoacoustic effect could invoke auditory response in infrared neuron stimulation.