Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

Abstract Background Worldwide, over 10 million individuals suffer from drug-resistant epilepsy. New therapeutic strategies are needed to address this debilitating disease. Inhibition of sodium-glucose linked transporters (SGLTs), which are variably expressed in the brain, has been demonstrated to re...

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Bibliographic Details
Main Authors: Mumin Alper Erdogan, Dimas Yusuf, Joanna Christy, Volkan Solmaz, Arife Erdogan, Emin Taskiran, Oytun Erbas
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Neurology
Subjects:
Dapagliflozin
Epilepsy
Pentylenetetrazol
Sodium-glucose linked transporter
Online Access:http://link.springer.com/article/10.1186/s12883-018-1086-4

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