Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one

Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one

Some new 3-(substituted)-chromen-2-one have been synthesized by condensation of 3-acetylchromen-2-one with various aromatic aldehyde in presence of ethanol and alkali. The synthesized compounds were identified by spectral data and screened for their antibacterial activity against B. pumilis, B. subs...

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Main Authors: B. Lakshminarayanan, V. Rajamanickam, T. Subburaju, L. A. Pradeep Rajkumar, H. Revathi
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2010/937903
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spelling doaj-8ee6cbc3aa3347b2840baa97941633d82020-11-24T22:27:32ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102010-01-017S1S400S40410.1155/2010/937903Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-oneB. Lakshminarayanan0V. Rajamanickam1T. Subburaju2L. A. Pradeep Rajkumar3H. Revathi4Karpagam College of Pharmacy , S.F.No:762, Othakkalmandapam, Coimbatore-641032, IndiaArulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, IndiaArulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, IndiaArulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, IndiaWockhardt Limited, Biotech Park, H-14/2 m.i.d.c. Area, Waluj, Aurangabad-431136, IndiaSome new 3-(substituted)-chromen-2-one have been synthesized by condensation of 3-acetylchromen-2-one with various aromatic aldehyde in presence of ethanol and alkali. The synthesized compounds were identified by spectral data and screened for their antibacterial activity against B. pumilis, B. substilis and E. coli and antifungal activity against A. niger and Candida albicans. Among the synthesized compounds, some compounds of aryl chromen, which are having electron releasing substituent such as methoxy and hydroxyl at various positions, showed moderate to considerable antibacterial and antifungal activities.http://dx.doi.org/10.1155/2010/937903
collection DOAJ
language English
format Article
sources DOAJ
author B. Lakshminarayanan
V. Rajamanickam
T. Subburaju
L. A. Pradeep Rajkumar
H. Revathi
spellingShingle B. Lakshminarayanan
V. Rajamanickam
T. Subburaju
L. A. Pradeep Rajkumar
H. Revathi
Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one
E-Journal of Chemistry
author_facet B. Lakshminarayanan
V. Rajamanickam
T. Subburaju
L. A. Pradeep Rajkumar
H. Revathi
author_sort B. Lakshminarayanan
title Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one
title_short Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one
title_full Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one
title_fullStr Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one
title_full_unstemmed Synthesis and Antimicrobial Activity of Some Aldehyde Derivatives of 3-Acetylchromen-2-one
title_sort synthesis and antimicrobial activity of some aldehyde derivatives of 3-acetylchromen-2-one
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2010-01-01
description Some new 3-(substituted)-chromen-2-one have been synthesized by condensation of 3-acetylchromen-2-one with various aromatic aldehyde in presence of ethanol and alkali. The synthesized compounds were identified by spectral data and screened for their antibacterial activity against B. pumilis, B. substilis and E. coli and antifungal activity against A. niger and Candida albicans. Among the synthesized compounds, some compounds of aryl chromen, which are having electron releasing substituent such as methoxy and hydroxyl at various positions, showed moderate to considerable antibacterial and antifungal activities.
url http://dx.doi.org/10.1155/2010/937903
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AT vrajamanickam synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one
AT tsubburaju synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one
AT lapradeeprajkumar synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one
AT hrevathi synthesisandantimicrobialactivityofsomealdehydederivativesof3acetylchromen2one
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