Humoral immune responses to EGFR-derived peptides predict progression-free and overall survival of non-small cell lung cancer patients receiving gefitinib.

Somatic mutations in the epidermal growth factor receptor (EGFR) gene are associated with clinical response to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib, in patients with non-small cell lung cancer (NSCLC). However, humoral immune responses to EGFR in NSCLC patients have not been wel...

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Bibliographic Details
Main Authors: Koichi Azuma, Nobukazu Komatsu, Satoshi Hattori, Satoko Matsueda, Akihiko Kawahara, Tetsuro Sasada, Kyogo Itoh, Tomoaki Hoshino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3909003?pdf=render