Role of neutral endopeptidase in endotoxin-induced bronchial hyperresponsiveness to substance P in guinea pigs

Role of neutral endopeptidase in endotoxin-induced bronchial hyperresponsiveness to substance P in guinea pigs

To investigate effects of endotoxin on allergic airway diseases, we studied bronchial responsiveness to histamine (HI) and substance P (SP) in actively sensitized and non-sensitized guinea pigs 24 h after exposure to endotoxin (75 (μg/mL; 40 min) and its vehicle, saline. Bronchial responsiveness to...

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Bibliographic Details
Main Authors: Shigenori Iwamae, Hideo Tsukagoshi, Takeshi Hisada, Daisuke Uno, Masatomo Mori
Format: Article
Language:English
Published: Elsevier 1998-01-01
Series:Allergology International
Subjects:
active sensitization
bronchial hyperresponsiveness
endotoxin
histamine
neutral endopeptidase
substance P
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015315331

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