Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway

<p>Abstract</p> <p>Background</p> <p>Elevated brain levels of the pleiotropic cytokine interleukin-6, which is mainly secreted from activated local astrocytes, contribute to pathological events including neuroinflammation and neurodegeneration. Thus, inhibition of patho...

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Bibliographic Details
Main Authors: Kehlen Astrid, Meyer Antje, Menge Katja, Zeitschel Ulrike, Niestroj André J, Engel Claudia, Schulz Ingo, Roßner Steffen, Demuth Hans-Ulrich
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Journal of Neuroinflammation
Subjects:
astrocytes
LPS mouse model
IL-6 expression
anti-inflammatory
STAT3 phosphorylation
p65 co-immunoprecipitation
Online Access:http://www.jneuroinflammation.com/content/8/1/86

Internet

http://www.jneuroinflammation.com/content/8/1/86

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