Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient

Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient

Diagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult. We report here a 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had other cutaneous papulovesicular...

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Main Authors: Shinsaku Imashuku, Miyako Kobayashi, Yoichi Nishii, Keisuke Nishimura
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Case Reports in Dermatological Medicine
Online Access:http://dx.doi.org/10.1155/2018/1680871
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spelling doaj-8ed3dd3d6c514b8cb0097879838eeeea2020-11-24T20:56:00ZengHindawi LimitedCase Reports in Dermatological Medicine2090-64632090-64712018-01-01201810.1155/2018/16808711680871Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly PatientShinsaku Imashuku0Miyako Kobayashi1Yoichi Nishii2Keisuke Nishimura3Department of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDepartment of Internal Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDivision of Plastic Surgery, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDepartment of Pathology, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDiagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult. We report here a 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had other cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. The patient was first successfully treated with multiagent chemotherapy (cytosine arabinoside/vinblastine/prednisolone). DDAVP also well controlled diabetes insipidus; however, the axillary ulcer and cutaneous LCH relapsed. Thereafter, we found topical imiquimod to be effective in the treatment of relapsed cutaneous LCH lesions.http://dx.doi.org/10.1155/2018/1680871
collection DOAJ
language English
format Article
sources DOAJ
author Shinsaku Imashuku
Miyako Kobayashi
Yoichi Nishii
Keisuke Nishimura
spellingShingle Shinsaku Imashuku
Miyako Kobayashi
Yoichi Nishii
Keisuke Nishimura
Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient
Case Reports in Dermatological Medicine
author_facet Shinsaku Imashuku
Miyako Kobayashi
Yoichi Nishii
Keisuke Nishimura
author_sort Shinsaku Imashuku
title Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient
title_short Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient
title_full Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient
title_fullStr Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient
title_full_unstemmed Topical Imiquimod for the Treatment of Relapsed Cutaneous Langerhans Cell Histiocytosis after Chemotherapy in an Elderly Patient
title_sort topical imiquimod for the treatment of relapsed cutaneous langerhans cell histiocytosis after chemotherapy in an elderly patient
publisher Hindawi Limited
series Case Reports in Dermatological Medicine
issn 2090-6463
2090-6471
publishDate 2018-01-01
description Diagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult. We report here a 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had other cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. The patient was first successfully treated with multiagent chemotherapy (cytosine arabinoside/vinblastine/prednisolone). DDAVP also well controlled diabetes insipidus; however, the axillary ulcer and cutaneous LCH relapsed. Thereafter, we found topical imiquimod to be effective in the treatment of relapsed cutaneous LCH lesions.
url http://dx.doi.org/10.1155/2018/1680871
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AT miyakokobayashi topicalimiquimodforthetreatmentofrelapsedcutaneouslangerhanscellhistiocytosisafterchemotherapyinanelderlypatient
AT yoichinishii topicalimiquimodforthetreatmentofrelapsedcutaneouslangerhanscellhistiocytosisafterchemotherapyinanelderlypatient
AT keisukenishimura topicalimiquimodforthetreatmentofrelapsedcutaneouslangerhanscellhistiocytosisafterchemotherapyinanelderlypatient
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