The Role of Caspase-2 in Regulating Cell Fate

Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family and has been implicated in both apoptotic and non-apoptotic signaling pathways, including tumor suppression, cell cycle regulation, and DNA repair. A myriad of signaling molecules is associated with the tight regul...

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Main Authors:	Vasanthy Vigneswara, Zubair Ahmed
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Series:	Cells
Subjects:	caspase-2 procaspase apoptosis splice variants activation intrinsic
Online Access:	https://www.mdpi.com/2073-4409/9/5/1259

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spelling	doaj-8ec198db02704c69bd6609aaf3f0e04d2020-11-25T03:22:08ZengMDPI AGCells2073-44092020-05-0191259125910.3390/cells9051259The Role of Caspase-2 in Regulating Cell FateVasanthy Vigneswara0Zubair Ahmed1Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UKNeuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UKCaspase-2 is the most evolutionarily conserved member of the mammalian caspase family and has been implicated in both apoptotic and non-apoptotic signaling pathways, including tumor suppression, cell cycle regulation, and DNA repair. A myriad of signaling molecules is associated with the tight regulation of caspase-2 to mediate multiple cellular processes far beyond apoptotic cell death. This review provides a comprehensive overview of the literature pertaining to possible sophisticated molecular mechanisms underlying the multifaceted process of caspase-2 activation and to highlight its interplay between factors that promote or suppress apoptosis in a complicated regulatory network that determines the fate of a cell from its birth and throughout its life.https://www.mdpi.com/2073-4409/9/5/1259caspase-2procaspaseapoptosissplice variantsactivationintrinsic
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vasanthy Vigneswara Zubair Ahmed
spellingShingle	Vasanthy Vigneswara Zubair Ahmed The Role of Caspase-2 in Regulating Cell Fate Cells caspase-2 procaspase apoptosis splice variants activation intrinsic
author_facet	Vasanthy Vigneswara Zubair Ahmed
author_sort	Vasanthy Vigneswara
title	The Role of Caspase-2 in Regulating Cell Fate
title_short	The Role of Caspase-2 in Regulating Cell Fate
title_full	The Role of Caspase-2 in Regulating Cell Fate
title_fullStr	The Role of Caspase-2 in Regulating Cell Fate
title_full_unstemmed	The Role of Caspase-2 in Regulating Cell Fate
title_sort	role of caspase-2 in regulating cell fate
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2020-05-01
description	Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family and has been implicated in both apoptotic and non-apoptotic signaling pathways, including tumor suppression, cell cycle regulation, and DNA repair. A myriad of signaling molecules is associated with the tight regulation of caspase-2 to mediate multiple cellular processes far beyond apoptotic cell death. This review provides a comprehensive overview of the literature pertaining to possible sophisticated molecular mechanisms underlying the multifaceted process of caspase-2 activation and to highlight its interplay between factors that promote or suppress apoptosis in a complicated regulatory network that determines the fate of a cell from its birth and throughout its life.
topic	caspase-2 procaspase apoptosis splice variants activation intrinsic
url	https://www.mdpi.com/2073-4409/9/5/1259
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The Role of Caspase-2 in Regulating Cell Fate

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