Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells

Amplification and propagation of interleukin-1β signaling by murine brain endothelial and glial cells

Abstract Background During acute infections and chronic illnesses, the pro-inflammatory cytokine interleukin-1β (IL-1β) acts within the brain to elicit metabolic derangements and sickness behaviors. It is unknown which cells in the brain are the proximal targets for IL-1β with respect to the generat...

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Bibliographic Details
Main Authors: Stephanie M. Krasnow, J. Gabriel Knoll, Santhosh Chakkaramakkil Verghese, Peter R. Levasseur, Daniel L. Marks
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Neuroinflammation
Subjects:
Interleukin-1β
Microglia
Astrocytes
Endothelium
Cytokines
NF-κB
Online Access:http://link.springer.com/article/10.1186/s12974-017-0908-4

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