Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells

Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells

<p>Abstract</p> <p>Background</p> <p>Since cholangiocarcinoma has a poor prognosis, several epidermal growth factor receptor (EGFR)-targeted therapies with antibody or small molecule inhibitor treatment have been proposed. However, their effect remains limited. The pres...

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Bibliographic Details
Main Authors: Gui Anping, Kobayashi Akira, Motoyama Hiroaki, Kitazawa Masato, Takeoka Michiko, Miyagawa Shinichi
Format: Article
Language:English
Published: BMC 2012-05-01
Series:BMC Cancer
Subjects:
Cholangiocarcinoma
RBE cells
EGFR
Tyrosine 1045
Down-regulation
Recycling
Target
Online Access:http://www.biomedcentral.com/1471-2407/12/179

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