Overcoming the UCB HSCs –Derived NK cells Dysfunction through Harnessing RAS/MAPK, IGF-1R and TGF-β Signaling Pathways

Overcoming the UCB HSCs –Derived NK cells Dysfunction through Harnessing RAS/MAPK, IGF-1R and TGF-β Signaling Pathways

Abstract Background The natural killer (NK) cells differentiated from umbilical cord blood (UCB) hematopoietic stem cells (HSCs) may be more suitable for cell-based immunotherapy compared to the NK cells from adult donors. This is due to the possibility to choose alloreactive donors and potentially...

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Bibliographic Details
Main Authors: Alireza Shokouhifar, Gholamreza Anani Sarab, Mahboubeh Yazdanifar, Mohammad Fereidouni, Masoumeh Nouri, Marzieh Ebrahimi
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Cancer Cell International
Subjects:
Umbilical cord blood
Natural killer cells
Differentiation
Cytotoxicity
Cancer immunotherapy
Online Access:https://doi.org/10.1186/s12935-021-01983-z

Internet

https://doi.org/10.1186/s12935-021-01983-z

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